Ameliorative efficacy of the sea cucumber Holothuria polii extract against the hepato-renal and lung toxicity induced by cyclophosphamide in adult male albino rat

Document Type : Original Article

Authors

Zoology Department, Faculty of Science, Damanhur University, Egypt

10.21608/BBJ.2025.382456.1102

Abstract

Cyclophosphamide (CTX) treatment for cancer has serious adverse effects on the liver, kidney, lungs, and other organs. This study evaluated the efficacy of Holothuria polii extract (HPE) in ameliorating liver, kidney, and lung tissues recovery from CTX-induced toxicity in rats’ model. The experimental rats were randomly divided into four groups (10 rats for each) as follows: Group 1 (Gp1) was served as a control group. In Gp2, rats were administered HPE (3.8 mg/kg b.wt) orally/day for eight consecutive days. Gp3, rats were received a single dose of CTX (200 mg/kg b.wt.) intraperitoneally (i.p.) injected. Gp4 rats were injected with CTX as in Gp3 and administered orally with HPE as in Gp2. Aspartate and alanine aminotransferases, albumin, total bilirubin, uric acid, creatinine, superoxide dismutase, catalase, glutathione reduced, malondialdehyde, angiotensinogen, angiotensin II, renin, aldosterone, tumor necrotic factor-α, interleukin-1 beta, caspase 3 and minerals were measured. Investigations were conducted on histological changes in the liver, kidney, and lung tissues. According to the findings, rats' liver, kidney, and lung histological structures and normal functioning were all changed by CTX injections.  HPE treatment post CTX injection improves histological structure and physiological functions.

Keywords

Main Subjects

Files

Share

How to cite

Statistics